March 2, 2014

Nanoparticle-mediated delivery targeting TAK1 as a metastatic breast cancer therapy

Investigators:Min Yu, M.D., Ph.D. Pin Wang, Ph.D., Julie Lang, M.D.
Innovation: delivering a novel nanoparticle/TAK1 inhibitor to halt metastasis
Clinical significance: a new treatment for metastatic breast cancer
March 2, 2014

Optimization of pH-sensitive peptide nanoconstructs for use in targeting the mildly acidic tumor microenvironment

Investigators: Jennica Zaro, Ph.D. Peter Conti, M.D., Ph.D.
Innovation: a method to recognize the minute differences in pH levels near tumor cells
Clinical significance: enabling more powerful cancer-killing drugs to be used without side effects
March 1, 2014

Focused microwave cancer therapy using lithographically defined nanoparticles

Investigators: Wei Wu, Ph.D.; Mahta Moghaddam, Ph.D.; John Stang, Ph.D.; Eugene Chung, M.D., Ph.D., J.D.
Innovation: a new class of custom-engineered nanoparticles that enhance absorption at microwave frequencies
Clinical significance: noninvasive, less painful therapy, especially beneficial for patients unable to undergo surgery
March 1, 2014

Nanoparticle-enhanced ultrasound therapy

Investigators: Andrea Armani, Ph.D.; Charles Gomer, Ph.D.; David Agus, M.D.; Qifa Zhou, Ph.D.
Innovation: combining nanotechnology with ultrasound waves
Clinical significance: increasing the penetration depth of nanoparticle- enhanced therapy to reach previously inaccessible tumors
March 1, 2013

Diagnostic imaging of smart genetically engineered nanomedicines

Investigators: J. Andrew MacKay, Ph.D.; Peter Conti, M.D., Ph.D.
Innovation: developing a timepoint-independent pharmacokinetic modeling strategy
Clinical significance: improving personalized medicine by more accurately measuring the effects of a particular treatment on an individual patient
March 1, 2013

Developing SUPR peptide diagnostics and therapeutics for oral cavity carcinomas

Investigators: Richard Roberts, Ph.D.; Uttam Sinha, M.D.
Innovation: develop high-affinity peptides for targeted diagnosis and a pipeline for generating other reagents
Clinical significance: a robust, simple diagnostic test for early detection of head and neck cancers