Innovative Ultrasound-Guided CAR-Macrophages for Safe and Effective Cancer Immunotherapy
July 18, 2023

Development of Novel Antibody-Drug Conjugates for Metastatic Breast Cancer

This application proposed to develop novel antibody-drug conjugates (ADCs) targeting a circulating tumor cells (CTCs)-associated antigen. By selectively killing CTCs through the delivered cytotoxic drugs, ADCs promise to eliminate brain metastasis-initiating CTCs and primary tumors shedding CTCs. If successful, this work will provide first-in-class targeted therapeutics for combating metastatic cancer and lead to a paradigm shift in cancer treatment.